刘建;王宪娥;吕达;乔敏;张立;孟焕新;徐莉;毛铭馨;

• 1:北京大学口腔医学院·口腔医院牙周科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室

摘要(Abstract)：

目的:探索广泛型侵袭性牙周炎(generalized aggressive periodontitis,GAg P)患者牙根形态异常与骨代谢或牙根发育相关基因多态性的关联。方法:纳入179例GAg P患者,平均(27.23±5.19)岁,男∶女=67∶112,平均存留牙数(26.80±1.84)颗。采用基于基质辅助激光解吸电离飞行时间质谱技术进行9个与骨代谢和牙根发育相关基因的13个单核苷酸多态性位点(single nucleotide polymorphisms,SNPs)的基因型检测。采用全口根尖片评判牙根形态异常,包括锥根、细长根、冠根比例失调、弯曲根、融合根、后牙根形态异常,分析13个SNPs位点不同基因型根形态异常牙的数量及发生率。结果:GAg P患者根形态异常牙构成比为14.49%(695/4 798颗),平均(3.88±3.84)颗。维生素D受体(vitamin D receptor,VDR)基因rs2228570位点的CC、CT、TT基因型患者根形态异常牙数量分别为(4.66±4.10)、(3.71±3.93)和(2.68±2.68)颗,CC基因型和TT基因型之间差异有统计学意义(t=2.62,P=0.01)。降钙素受体(calcitotin receptor,CTR)基因rs2283002位点CC、CT、TT基因型患者根形态异常数分别为(5.02±3.70)、(3.43±3.95)、(3.05±3.12)颗,CC基因型的根形态异常发病率高于CT和TT基因型(87.86%vs.65.26%和63.64%,P=0.006,adjusted OR=3.71,95%CI:1.45～9.50)。结论:VDR rs2228570及CTR rs2283002位点可能与广泛型侵袭性牙周炎患者牙根形态异常的发生有关,值得进一步研究。

关键词(KeyWords)： 侵袭性牙周炎;牙根形态异常;基因;单核苷酸多态性

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘建;王宪娥;吕达;乔敏;张立;孟焕新;徐莉;毛铭馨;

Email:

DOI: 10.19723/j.issn.1671-167X.2021.01.004

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